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Sertraline (trade names Zoloft and others) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline is primarily prescribed for major depressive disorder in adult outpatients as well as obsessive-compulsive disorder, panic disorder, and social anxiety disorder, in both adults and children. Differences with other newer antidepressants are subtle and mostly confined to side effects.
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In 2013, it was the most prescribed antidepressant and second most prescribed psychiatric medication (after alprazolam) on the U. It has a similar tolerability profile to other SSRIs, with the types of adverse events usually including diarrhea, nausea, and sexual dysfunction.
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Antidepressants for teenagers and children have become a controversial topic thanks to all the evidence that is surfacing linking the side effects of these drugs to suicides and violent behavior.
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Fluoxetine, (Prozac) was the first SSRI (selective serotonin reuptake inhibitor) to be approved in the United States for use in depression. Although it was not FDA approved for use in depressed children until early 2003, clinicians widely used this type of medication to treat children and adolescents with depression and anxiety.
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